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immunum

Fast antibody and T-cell receptor numbering, in your browser.

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Load example:
Chains
Scheme
Min. confidence 0.50

How to read the result

  • Sequence: your whole input, coloured by the region each residue falls in: FR1 to FR4 and CDR1 to CDR3. Hover over a stretch to see its domain and region.
  • Flank: grey residues outside every domain. A domain's prefix holds the residues before it, back to the previous domain or the start of the sequence (a leader, or the linker of an scFv); the last domain's postfix holds the residues after it. See Prefix and postfix.
  • Query: the residues of your input that the domain's alignment covers, counted from 1 and inclusive. The APIs report the same range 0-based, as queryStart/queryEnd (query_start/ query_end in Python and the CLI).
  • Confidence: how well the domain aligns to the chain it was assigned, from 0 to 1. A domain below the minimum confidence isn't numbered. See Confidence.
  • Numbering: one box per numbered residue, with its position in the chosen scheme above it. A position with a letter, such as 111A, is an insertion: a residue the scheme has no plain number for. In IMGT CDR3 insertions grow from the middle, so 111A follows 111 and 112A comes before 112; Kabat, Chothia and Martin append them after the number (100, 100A, 100B). Positions missing from the run, such as IMGT 10 in the IGH example, are gaps: the sequence has no residue there.
  • Compare schemes: per domain, where each scheme puts the FR/CDR boundaries for that chain and which residues each scheme calls CDRs. Only IMGT numbers TCR chains.
  • Copy link: a URL holding the sequence and settings; opening it numbers the sequence again. Downloads use the columns and keys of the CLI's immunum number --all-domains output, and the JSON adds each domain's segments.

Resources

crates.io

The Rust crate on crates.io.

docs.rs

API documentation for the Rust crate.

PyPI

The Python package.

npm

The WASM package for JavaScript and TypeScript.